A Lightweight Distributed Solution to Content Replication in Mobile Networks

Performance and reliability of content access in mobile networks is conditioned by the number and location of content replicas deployed at the network nodes. Facility location theory has been the traditional, centralized approach to study content replication: computing the number and placement of replicas in a network can be cast as an uncapacitated facility location problem. The endeavour of this work is to design a distributed, lightweight solution to the above joint optimization problem, while taking into account the network dynamics. In particular, we devise a mechanism that lets nodes share the burden of storing and providing content, so as to achieve load balancing, and decide whether to replicate or drop the information so as to adapt to a dynamic content demand and time-varying topology. We evaluate our mechanism through simulation, by exploring a wide range of settings and studying realistic content access mechanisms that go beyond the traditional assumptionmatching demand points to their closest content replica. Results show that our mechanism, which uses local measurements only, is: (i) extremely precise in approximating an optimal solution to content placement and replication; (ii) robust against network mobility; (iii) flexible in accommodating various content access patterns, including variation in time and space of the content demand.Comment: 12 page

The association between diabetes and gastric cancer

Background: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective: To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable to chronic respiratory diseases through an analysis of deaths, disability-adjusted life-years (DALYs), and years of life lost (YLL) by GBD super-region, from 1990 to 2017, stratified by age and sex. Specific diseases analysed included asthma, COPD, interstitial lung disease and pulmonary sarcoidosis, pneumoconiosis, and other chronic respiratory diseases. We also assessed the contribution of risk factors (smoking, second-hand smoke, ambient particulate matter and ozone pollution, household air pollution from solid fuels, and occupational risks) to chronic respiratory disease-attributable DALYs. Findings In 2017, 544.9 million people (95% uncertainty interval [UI] 506.9- 584.8) worldwide had a chronic respiratory disease, representing an increase of 39.8% compared with 1990. Chronic respiratory disease prevalence showed wide variability across GBD super-regions, with the highest prevalence among both males and females in high-income regions, and the lowest prevalence in sub-Saharan Africa and south Asia. The age-sex- specific prevalence of each chronic respiratory disease in 2017 was also highly variable geographically. Chronic respiratory diseases were the third leading cause of death in 2017 (7.0% [95% UI 6.8-7 .2] of all deaths), behind cardiovascular diseases and neoplasms. Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578-4 044 819) in 2017, an increase of 18.0% since 1990, while total DALYs increased by 13.3%. However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14.3% decrease), agestandardised death rates (42.6%), and age-standardised DALY rates (38.2%). In males and females, most chronic respiratory disease-attributable deaths and DALYs were due to COPD. In regional analyses, mortality rates from chronic respiratory diseases were greatest in south Asia and lowest in sub-Saharan Africa, also across both sexes. Notably, although absolute prevalence was lower in south Asia than in most other super-regions, YLLs due to chronic respiratory diseases across the subcontinent were the highest in the world. Death rates due to interstitial lung disease and pulmonary sarcoidosis were greater than those due to pneumoconiosis in all super-regions. Smoking was the leading risk factor for chronic respiratory disease-related disability across all regions for men. Among women, household air pollution from solid fuels was the predominant risk factor for chronic respiratory diseases in south Asia and sub-Saharan Africa, while ambient particulate matter represented the leading risk factor in southeast Asia, east Asia, and Oceania, and in the Middle East and north Africa super-region. Interpretation Our study shows that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990. Premature mortality from chronic respiratory diseases seems to be highest in regions with less-resourced health systems on a per-capita basis

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: A systematic analysis for the global burden of disease study 2017

© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable to chronic respiratory diseases through an analysis of deaths, disability-adjusted life-years (DALYs), and years of life lost (YLL) by GBD super-region, from 1990 to 2017, stratified by age and sex. Specific diseases analysed included asthma, COPD, interstitial lung disease and pulmonary sarcoidosis, pneumoconiosis, and other chronic respiratory diseases. We also assessed the contribution of risk factors (smoking, second-hand smoke, ambient particulate matter and ozone pollution, household air pollution from solid fuels, and occupational risks) to chronic respiratory disease-attributable DALYs. Findings: In 2017, 544·9 million people (95% uncertainty interval [UI] 506·9–584·8) worldwide had a chronic respiratory disease, representing an increase of 39·8% compared with 1990. Chronic respiratory disease prevalence showed wide variability across GBD super-regions, with the highest prevalence among both males and females in high-income regions, and the lowest prevalence in sub-Saharan Africa and south Asia. The age-sex-specific prevalence of each chronic respiratory disease in 2017 was also highly variable geographically. Chronic respiratory diseases were the third leading cause of death in 2017 (7·0% [95% UI 6·8–7·2] of all deaths), behind cardiovascular diseases and neoplasms. Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while total DALYs increased by 13·3%. However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14·3% decrease), age-standardised death rates (42·6%), and age-standardised DALY rates (38·2%). In males and females, most chronic respiratory disease-attributable deaths and DALYs were due to COPD. In regional analyses, mortality rates from chronic respiratory diseases were greatest in south Asia and lowest in sub-Saharan Africa, also across both sexes. Notably, although absolute prevalence was lower in south Asia than in most other super-regions, YLLs due to chronic respiratory diseases across the subcontinent were the highest in the world. Death rates due to interstitial lung disease and pulmonary sarcoidosis were greater than those due to pneumoconiosis in all super-regions. Smoking was the leading risk factor for chronic respiratory disease-related disability across all regions for men. Among women, household air pollution from solid fuels was the predominant risk factor for chronic respiratory diseases in south Asia and sub-Saharan Africa, while ambient particulate matter represented the leading risk factor in southeast Asia, east Asia, and Oceania, and in the Middle East and north Africa super-region. Interpretation: Our study shows that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990. Premature mortality from chronic respiratory diseases seems to be highest in regions with less-resourced health systems on a per-capita basis. Funding: Bill & Melinda Gates Foundation

Réplication de contenu dans les réseaux sans fil mobiles

The growth of mobile devices and network-based services nowadays has raised a timely question on how to efficiently distribute the data items to mobile users. Network applications need data as an input to process and provide information to users. Consequently, data traffic exerted by mobile devices fetching content is a drainage of mobile operators' network resources. Similar to the wired Internet, mobile users are now coping with the congestion at network gateways and due to the unpredictability of human mobility, mobile service providers cannot sufficiently provision infrastructures for their customers. Content replication in this context has been proved as a good solution to enhance network performance and scalability. In this thesis, we tackle the issues of content replication in heterogeneous mobile networks. Such scheme requires us to solve two basic questions: where and how many replicas should be placed in the system. We study the solution through the lenses of facility location theory and design a distributed mechanism that reduces content access latency and avoids congestion at mobile gateways. Additionally, we consider the resource constraints of mobile devices and introduce a P2P cache-and-forward mechanism for load balancing purpose. We evaluate our mechanisms against realistic human mobility models. Finally, to address rational users who may behave selfishly in replicating content, we derive a cost model and study content replication scheme using tools akin to game theory. We focus on the replication factor under a flash-crowd scenario with different wireless bit rates. Based on the theoretical findings, our future work is to develop the strategies to be implemented in a practical network setting.La croissance des terminaux et des services de réseau mobile pose aujourd'hui une question sur la méthode de distribuer efficacement des données aux utilisateurs. Plusieurs applications de réseau ont besoin de télécharger des données afin de fournir des informations aux utilisateurs. En conséquence, l'explosion du trafic de données exercé par les clients qui cherchent des contenus en ligne provoque la saturation du réseau cellulaire des opérateurs mobiles. Similaire aux problèmes du réseau Internet, les utilisateurs mobiles ont désormais fait face à la congestion au niveau des passerelles de réseau. En raison de l'imprévisibilité de la mobilité humaine, les fournisseurs de services mobiles ne peuvent pas installer suffisamment des infrastructures pour leurs clients. La réplication de contenu dans ce contexte a été prouvée comme une bonne solution pour améliorer la performance et l'extensibilité du réseau. Dans cette thèse, nous abordons les problèmes de la réplication du contenu dans des réseaux hétérogènes mobiles. Nous étudions deux questions fondamentales: où et combien de répliques doivent être placées dans le système. Nous modélisons le problème à l'aide de la théorie de "facility location" et nous concevons un mécanisme distribué qui est capable de réduire la latence d'accès au contenu et d'éviter la congestion au niveau des passerelles mobiles. En outre, nous examinons les contraintes de ressources des équipements mobiles et proposons des mécanismes P2P pour transférer les répliques afin de parvenir l'équilibrage de charge parmi les utilisateurs. Nous évaluons nos mécanismes en utilisant des modèles de mobilité humaine. Enfin, pour résoudre le problème causé par les utilisateurs rationnels qui se comportent égoïstement lors de la réplication du contenu dans les réseaux hétérogènes mobiles, nous dérivons un modèle de coût et utilisons la théorie des jeux pour étudier les équilibres du système. Particulièrement, nous étudions le facteur de réplication dans un scénario "flash-crowd" avec de différents débits de réseau sans fil. A partir des résultats théoriques, nos futurs travaux sont d'élaborer des stratégies à mettre en œuvre dans les réseaux en pratique